Thursday, February 28, 2013

Natural ways to manage spring allergies

Millions suffer from these bothersome indoor/outdoor allergies, but before you pick up the usual prescription or over-the-counter remedy, here are a few natural ways to manage the common symptoms of incessant coughing, runny nose, itchy eyes and sore throat.

While pollutants like asbestos and smoke fumes, as well as seasonal conditions like dust, pollen and mold spores contribute to respiratory allergies, "this type of allergy often occurs when the body has an excess accumulation of mucus, which harbors environment irritants," says Dr. Lindsey Duncan, ND, CN.

"Common drugstore medications generally mask symptoms and also have a rebound effect ? the more you use them, the more you need them," Dr. Duncan warns. "When taken for long periods, steroid drugs do not cure and often make hay fever allergies worse by depressing immune defenses and impeding allergen elimination."

Detox your diet

fish oil

To alleviate allergies, Dr. Duncan advises we eat non-mucus-forming foods such as fresh vegetables and fruits, whole grains, foods with active cultures (like yogurt), foods high in vitamin C like citrus and berries, oily seafood and sulfur-rich cabbage, onions and garlic.

This suggested program "will help detoxify your blood, support your liver, neutralize histamine reactions and neutralize allergen response," she says.

Additionally, get plenty of essential fatty acids from omega-3 oils like flax, sea greens and spinach. Avoid inflammatory preserved and canned foods, sugary foods, caffeine and fatty mucus-forming foods (especially dairy products). Fasting can also assist in clearing allergy symptoms.

Naturopathic doctor Thalia Farshchian?s favorite seasonal allergy cure is drinking three to five cups of nettle tea throughout the day.

"This natural anti-histamine helps the liver detoxify allergens more efficiently and significantly reduces symptoms," Dr. Farshchian says. Other herbs that support avoiding allergies include dandelion (also found in tea form) and milk thistle.

Dr. Elizabeth Trattner, AP, DOM recommends boosting your immune system with fish oil at least one month before allergy season starts.

"Studies have demonstrated that fish oil is an excellent natural anti-inflammatory. Look for fish oil with high doses of EPA, one of the acids in fish oil that decreases inflammation," says Dr. Trattner.

She says to take at least 2,000 mg of EPA a day, with food, before 3 p.m. since "fish oil can cause insomnia in approximately 10 percent of the population who consumes it."

But if you don?t fancy fish oil supplements, go straight to the source and eat oily fish like salmon, mackerel, herring, sardines and albacore tuna, which are loaded with omega-3 fatty acids,?two to three times per week.

Clean up your environment

One simple way to avoid an allergic reaction is to keep your bedroom free of pollen and dust. Dr. Trattner recommends investing in a good HEPA filter to purge the air in the bedroom of mold spores, pollen, pet dander, smoke and dust.

She also advises removing the shoes and clothing you wear during the day before you enter the bedroom; decluttering so dust is less likely to collect on the carpet and drapery; and using only natural and unscented household products, dryer sheets, shampoos and laundry soap to decrease the chemical load on your body.

Pet owners should bathe and brush their furry friends frequently because "their fur can hold on to pollen and other allergens that can exacerbate your allergies."

CigaretteMake necessary lifestyle changes

It sounds like common sense, but allergy suffers may need a gentle reminder to stop smoking and to avoid secondary smoke. "[Smoke] magnifies allergy reactions," says Dr. Duncan.

Regular exercise helps boost the immune system, so incorporate a variety of physical activity into your routine including cardiovascular exercise, yoga and tai chi. During allergy season, however, Dr. Trattner recommends you work out indoors to lower your exposure to pollen in the air.

For allergy relief, licensed acupuncturist and certified herbalist Lexi Hagenson recommends weekly acupuncture treatments for a month or two.

"This 3,000-year-old Chinese practice can remarkably improve quality of life for allergy sufferers, even those who don't see results from conventional anti-allergy medications," says Hagenson, who adds that relief can come after just one session.

"Acupuncture works both locally by [alleviating]?head, neck and facial symptoms, and throughout the body by promoting healthy circulation and decreasing areas of hypersensitivity and stagnation."

Use a neti pot three to five times a week

Yes, pouring a saline solution from that little pot into your nose can work wonders. A neti pot can be found in most health food stores; simply follow the directions on the package.

"For thousands of years, ayurvedic medicine has used this simple nasal irrigation system to soothe and protect nasal passages," says Hagenson.

"It's the most effective way to remove pollen, dust,?environmental irritants and mucus from your sinuses, without causing dryness or rebound congestion often experienced from pharmaceutical decongestants."

More on allergies

Cut down on allergens in your child?s bedroom
Cope with your child's summer allergies on the cheap
What to expect from allergy shots

Source: http://www.sheknows.com/health-and-wellness/articles/986115/natural-ways-to-manage-spring-allergies

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Stocks surge, Dow nears record high

NEW YORK (AP) ? The Dow came within 60 points of its all-time high Wednesday after rising sharply for a second straight day.

The market surged following more evidence that the Fed will keep interest rates low, housing will keep recovering and shoppers aren't pulling back on spending, though they're paying more in Social Security taxes this year.

The gains were broad: Twenty-nine of 30 stocks in the Dow Jones industrial average rose. All 10 industries in the Standard and Poor's 500 index climbed.

The Dow Jones industrial average closed up 175.24 points, or 1.2 percent, to 14,075.37. The index is now 89 points from its record close of 14,164.53 reached in October 2007. The index rose steadily from the opening bell, then peaked near the record at 3:26 p.m. Eastern Time, before easing slightly in the last half hour of trade.

The Dow has surged 290 points in the past two days, erasing its drop of 216 points Monday when inconclusive results from an election in Italy renewed worries that Europe's fiscal crisis could flare up again.

"The market psychology has clearly shifted. It's no longer sell the rally, it's buy the dips," said Dan Veru, chief investment officer of Palisade Capital Management. "The economic data continues to be strong."

The Standard and Poor's 500 index gained 19.05 points, or 1.3 percent, to 1,515.99. The Nasdaq composite rose 32.61 points, or 1.3 percent, to 3,162.26. The index is 6.5 percent higher for the year, and is about 3.1 percent short of its record close of 1,565.

Investors were also encouraged Wednesday that Federal Reserve Chairman Ben Bernanke stood behind the central bank's low-interest-rate policies as he faced the House Financial Services Committee. His comments dissipated worries about the bank's resolve to keep up the program. Those worries sprang up last week when minutes from the bank's last policy meeting revealed disagreement among Fed officials.

Also, the number of Americans who signed contracts to buy homes rose in January from December to the highest level in almost three years. The report continued a string of positive housing news. Sales of new homes jumped 16 percent last month to the highest level since July 2008, the government reported Tuesday.

Home builder stocks rose for the second day in a row. PulteGroup climbed 25 cents, or 1.3 percent, to $19.30, after rising 5.7 percent the day before.

"Some encouraging news for the bulls has been the housing data that has come out over the past couple of days," said Todd Salamone, director of research at Schaeffer's Investment Research.

The analyst said he remained "extremely bullish," on stocks in the medium and long-term, but cautioned that a pullback may lie ahead in coming days after the year's strong gains.

Stocks have surged since the start of the year. The Dow is up 7.4 percent and the S&P 500 has climbed 6.3 percent.

But rising even more is the Dow Jones transportation average, which is up 13 percent for the year to 5,989.37. Airlines like Delta and Alaska Air are powering the gains.

"If the economy is doing well you've got to be moving stuff around," said Phil Orlando, chief equity strategists at Federated Investors. "You've got to be moving people on airplanes, you've got to be moving cargo with trains or trucks, or UPS."

Discount retailers rose Wednesday. Dollar Tree jumped $4.31, or 11 percent, to $45.39 after reporting a 22 percent profit increase. Dollar General rose $1.61, or 3.6 percent, to $46.56. Family Dollar Stores rose $1.39, or 2.5 percent, to $57.68.

Earnings for S&P 500 companies will climb 7.8 percent in the fourth quarter, the third straight quarter of growth, according to data from S&P Capital IQ.

The yield on the 10-year Treasury note rose two basis points to 1.90 percent.

Among other stocks making big moves;

? Retailer J.C. Penney fell $3.07, or 15 percent, to $18.09 after the market closed following a much a quarterly loss that was much larger than expected.

? Priceline.com rose $17.42, or 2.6 percent, to $695.91 after reporting that its net income jumped in the fourth quarter as bookings grew.

? First Solar plunged $4.32, or 13.8 percent, to $27.04 after the company posted disappointing sales for the fourth quarter and gave a weak early outlook for the year.

? Target fell 93 cents, or 1.5 percent, to $63.12 after the No. 2 discount chain's quarterly income fell 2 percent as it dealt with intense competition during the holiday shopping season.

? DreamWorks Animation fell 30 cents, or 1.8 percent, to $16.31 after posting a loss of $82.7 million. The company booked a write-off on its November release "Rise of the Guardians" and on an upcoming movie that needs to be reworked.

Source: http://news.yahoo.com/stocks-surge-housing-dow-nears-record-220328561--finance.html

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Study reveals stem cells in a human parasite

Tuesday, February 26, 2013

From the point of view of its ultimate (human) host, the parasitic flatworm Schistosoma mansoni has a gruesome way of life. It hatches in feces-tainted water, grows into a larva in the body of a snail and then burrows through human skin to take up residence in the veins. Once there, it grows into an adult, mates and, if it's female, starts laying eggs. It can remain in the body for decades.

A new study offers insight into the cellular operations that give this flatworm its extraordinary staying power. The researchers, from the University of Illinois, demonstrated for the first time that S. mansoni harbors adult, non-sexual stem cells that can migrate to various parts of its body and replenish tissues. Their report appears in the journal Nature.

According to the World Health Organization, more than 230 million people are in need of treatment for Schistosoma infections every year. Most live in impoverished areas with little or no access to clean water. Infection with the worm (also known as a blood fluke) can lead to damaging inflammation spurred by the presence of the worm's eggs in human organs and tissues.

"The female lays eggs more or less continuously, on the order of hundreds of eggs per day," said U. of I. cell and developmental biology professor and Howard Hughes Medical Institute Investigator Phillip Newmark, who led the study with postdoctoral researcher James J. Collins III.

"The eggs that don't get excreted in the feces to continue the life cycle actually become embedded inside host tissues, typically the liver, and those eggs trigger a massive inflammatory response that leads to tissue damage."

Children are especially vulnerable to the effects of infection, in some cases experiencing delays in growth and brain development as a result of chronic inflammation brought on by the parasites.

The new study began with an insight stemming from years of work on a different flatworm, the planarian, in Newmark's lab. Collins thought that schistosomes might make use of the same kinds of stem cells (called neoblasts in planarians) that allow planarians to regenerate new body parts and organs from even tiny fragments of living tissue.

"It just stood to reason that since schistosomes, like planaria, live so long that they must have a comparable type of system," Collins said. "And since these flatworms are related, it made sense that they would have similar types of cells. But it had never been shown."

In a series of experiments, Collins found that the schistosomes were loaded with proliferating cells that looked and behaved like planarian neoblasts, the cells that give them their amazing powers of regeneration. Like neoblasts, the undifferentiated cells in the schistosomes lived in the mesenchyme, a kind of loose connective tissue that surrounds the organs. And like neoblasts, these cells duplicated their DNA and divided to form two "daughter" cells, one of which copied its DNA again, a process that normally precedes cell division.

"Stem cells do two things," Newmark said. "They divide to make more stem cells and they give rise to cells that can differentiate."

Collins had labeled the cells with fluorescent markers. This allowed him to watch how they behaved. He noted that over the course of a few days, some of the labeled cells migrated into the gut or muscle, to become part of those tissues.

"We label the cells when they're born and then we see what they grow up to become," Collins said. "This is not conclusive evidence that these cells are equivalent to the planarian neoblasts, but it is consistent with the hypothesis that they are."

The researchers went deeper, determining which genes were turned on or off, up or down in the proliferating cells as compared with the non-dividing cells. They identified a gene in the proliferating cells that coded for a growth factor receptor very similar to one found in planarians. When the researchers switched off the parasite's ability to make use of this gene (using a technique called RNA interference in worms grown in the lab), the proliferating cells gradually died out.

"We postulated that these cells are important for the longevity of the parasite," Collins said. "Now we can start asking which genes regulate these cells."

"We started with the big question: How does a simple parasite survive in a host for decades?" Newmark said. "That implies that it has ways of repairing and maintaining its tissues. This study gives us insight into the really interesting biology of these parasites, and it may also open up new doors for making that life cycle a lot shorter."

###

University of Illinois at Urbana-Champaign: http://www.uiuc.edu

Thanks to University of Illinois at Urbana-Champaign for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/127019/Study_reveals_stem_cells_in_a_human_parasite

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Legislators take on proposal to legalize same-sex marriage (Star Tribune)

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Wednesday, February 27, 2013

The Seedbed of Civic Involvement Otis White

Everything works better in cities with high levels of citizen involvement. Social scientists tell us that politics are kinder when more people pay attention to government and vote, and social problems are diminished when people are close to their neighbors. Quality of life improves when people support festivals and attend local concerts and shows. Cities look better if people turn out for neighborhood cleanups and park conservancy projects. And when trouble comes?a big local industry closes or a natural disaster strikes?people are far more likely to see things through when they?re involved and invested in the place they live.

If civic involvement can do all these things, then there?s really only one big question: Where do you begin? Assuming yours is not a place where people vote in high numbers, check up on their neighbors, and turn out in large numbers for cleanup projects, what can governments and civic organizations do to get it started?

Answer: They can help people find one another and get organized for any legitimate purpose: recreation, self-improvement, religious, family betterment, education. And then be patient.

This won?t satisfy impatient leaders who want people involved in high-level civic work . . .? now!? How about calling some town-hall meetings or starting a citizens commission? You can do that, and if you do it well, you might see some improvement in community involvement. But if you want deeper, long-term change?big shifts in how citizens relate to one another and to the community?you need to work on the seedbed of civic involvement, which is self-interest plus connection plus organization. Then trust that these seeds will grow into a more involved citizenry.

Why begin with the seedbed? Because most people who are leaders in their communities didn?t start out as involved citizens; they grew into the role. A few had jobs that took them into local politics or civic causes, but the vast majority came up through volunteer work. And their first experiences with volunteering were usually about things in their immediate areas of interest (family, home, recreation, etc.). Go through the biographies of your city?s elected officials and you?ll find many started out volunteering for the PTA and got drawn into school district issues, or were on a neighborhood association board and got interested in local politics, or were active in a bicycling club and got caught up in a campaign for bike lanes. Once they figured out how things worked in their community, they were hooked.

This, then, is one reason you start with the seedbed: Multiply the number of opportunities for volunteer leadership, and in time you?ll multiply the number of deeply involved civic leaders. It won?t happen quickly. And not all the seedlings will grow into city leaders; many will be happy to serve in the PTA for years, or organize neighborhood cookouts, or teach safety classes to generations of young cyclists.

And that brings us to the second reason for tending the seedbed: Just as healthy forests don?t need all trees to be tall, we don?t need only highly involved civic leaders. We need moderately involved citizens, too: People who vote, serve on PTA committees, volunteer as Scout leaders and soccer coaches, turn out for neighborhood projects, and make small donations to good causes. Just as leaders do, these people strengthen their communities.

I can see this in my own life. My mother belonged to a business women?s club that, as far as I could tell, functioned as a social organization that, on the side, gave out college scholarships. Mostly, though, it just met, listened to speakers, and socialized. The scholarships were a good thing for the community, helping a few deserving students along the way. But an even better thing may have been the connections that these women forged as they helped one another in their careers. Who knows how many of them stayed in my hometown because of this network, enriching the community?s human capital?

We?ve known about this link between social networks and healthy communities for more than a decade, since Harvard Professor Robert Putnam wrote his book ?Bowling Alone.? It was a convincing look at the decline of what Putnam called ?social capital,? the connections that people have with one another. Where Americans once played bridge in foursomes, bowled in leagues, and joined Kiwanis Clubs to meet other business people, we now spend time in cars commuting long distances or in front of TVs or home computers. Putnam learned that people still do bowl; they just don?t do so in leagues. Rather, most bowl alone or as couples. Without the leagues, the bridge parties, the Kiwanis Clubs, and all the other group activities, modern Americans don?t form relationships and work for common purposes as easily as they once did. And this, he warned, threatens healthy communities and democracy itself.

Putnam?s book was a brilliant but depressing analysis of the problem that didn?t give us many starting points for changing things. But a new book and a think-tank report from the U.K. do. They point us to simple ways for connecting people around shared interests, by using a few incentives and a little help.

The book is ?Unanticipated Gains? by Mario Luis Small, a sociology professor at the University of Chicago. As the title suggests, it was about something surprising: the rich networks of support that some families in New York developed when their children were young.

His study focused on mothers from a variety of socioeconomic backgrounds who had children in day care centers. Parents turn to centers, of course, for economic or professional reasons: They have to work or want to work, and they need a safe, nurturing place for their children for a portion of the day. You?d think that the interactions of mothers and fathers dropping off and picking up small children would be hurried and, therefore, not great for creating connections. But some centers, Small found, had very effective ways of bringing parents together and connecting them with the city around them.

The keys were that some centers required parents to do something in addition to leaving and picking up their children: organize a field trip, serve on a parents? advisory committee, raise money, and so on. And some were good at connecting parents with needs with resources elsewhere in the community. As a result, through these centers, some parents got a lot more than child care; they gained lifelong friends, new resources, and much closer connections with the community.

What was important, Small said, were the activities the parents were asked to do. If the work was organized by the parents themselves, which required understanding, and the interactions were repeated, which built trust, friendships grew even among parents who were not much alike. This is particularly important in multi-cultural communities where people often don?t recognize themselves in their neighbors.

And some of the centers were more than good facilitators, Small found. They were good brokers of information. That is, they could help parents find information and get help outside their neighborhoods, by showing them how to navigate the public school system, get help in domestic abuse cases, find doctors and hospitals, even get family tickets to museums and circuses.

What does this have to do with civic work? As my mother?s business women?s network did in my hometown, it made it far more likely these families would stay in New York and be successful there. It meant their children would also be more likely to succeed. And simply having a network of friends?and a stake in the city?meant for many that they would take greater ownership in and care of the community. People with friends are less likely to litter, deface property with graffiti, or ignore criminal activity. And they are more likely to vote, volunteer for good causes, and care about their neighbors.

And something else. This kind of self-interested volunteering teaches people the basics of leadership: organizing meetings, managing projects, finding resources, handling disputes, negotiating with other interests. Some will take these skills to larger venues.

With the New York day care centers, government had a hand in getting the parents connected. Centers that served low-income families and received state aid were required to have parent advisory committees. That incentive alone got some centers started in involving parents, although the smart ones went well beyond that.

Governments can?t require other forms of volunteerism, of course. All they can do is encourage and facilitate it. But that can be a powerful tool, as a report from a British think tank argues. The report is called ?Clubbing Together: The Hidden Wealth of Communities,? and it argues that ?casual connections? among citizens can be generated with little effort and cities can play a big role in doing so by making it easier for people to meet.

What are ?casual connections?? They could be anything from people playing bingo to weekend sports leagues (think of softball leagues here, soccer there). These connections introduce people to one another, promote ethnic understanding, create ?sentiments of trust, reciprocity, and purpose,? and in time ?spur members into social actions, such as voluntary work or charitable giving,? the report says. In other words, they act as seedbeds.

This brings me to the great opportunity for communities. They have lots of places for people to meet, from playgrounds and softball fields to libraries and community centers. And with a little imagination, they could multiply the number of meeting places tenfold: school cafeterias, museum lobbies, concert halls, city hall meeting rooms, college classrooms, YMCAs. There are private spaces too, such as coffee shops, apartment clubhouses, and (yes!) bowling alleys that could be induced to open their doors to citizens?and potential customers?if there were property tax breaks involved. We could also make it easy for groups to find these spaces, with online reservations. (Attention, community hackathons!)

But what about security and cleanup? Organizers could sign forms assuming responsibility for hauling out trash and locking the doors. Would it work? I?ve been involved in scores of public meetings in schools, churches, and recreation centers over the years. I?ve never seen a volunteer group?even an informal one?refuse to take these responsibilities seriously.

But there?s a lesson here too. Much like mulch in a real seedbed, trust is the ingredient that enriches civic seedbeds. Yes, once in a while, you will be disappointed when a group doesn?t clean up the school cafeteria as it promised. But as you?re obsessing about the few, be sure to look about you and see all the healthy trees that are growing up.

?

Photo by Pictoscribe licensed under Creative Commons.

Source: http://otiswhite.com/?p=273

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Tuesday, February 26, 2013

Israel says it successfully tests new missile defense

JERUSALEM (Reuters) - Israel carried out a successful test of its upgraded Arrow interceptor system on Monday, which is designed to destroy in space the kind of missiles held by Syria and Iran, the Israeli Defense Ministry said.

The U.S.-backed Arrow III system deploys "kamikaze" satellites that target ballistic missiles above the earth's atmosphere, hitting them high enough to allow for any non-conventional warheads to disintegrate safely.

Monday's test was the first live flight for the Arrow III, but did not involve the interception of any target.

"The test examined for the first time the capabilities and the performance of the new Arrow III, considered to be the most innovative and revolutionary interceptor in the world," the Defense Ministry said.

A ministry official said the test, which was conducted from a site along Israel's Mediterranean coast and lasted six and a half minutes, was "100 percent successful".

Designers say the system has proved a success in up to 90 percent of previous tests.

"The success of the test is an important milestone in the operational capabilities of the state of Israel to be able to defend itself against threats in the region," the ministry statement added.

But the ministry official said the timing of the test, which took months to prepare, was not related to current tensions with Iran or Syria. He said Israel plans another flight test followed by a simulated interception in space over the Mediterranean.

U.S. BACKING

Arrow is the long-range segment in Israel's three-tier missile shield. This also includes the successfully deployed "Iron Dome", which targets short-range rockets and projectiles, and the mid-range "David's Sling", still under development. They can be deployed alongside other U.S. systems.

Officials say that if Arrow failed to hit an incoming missile at high altitude, there would still be time to destroy it with other systems before it hit its intended target.

The Pentagon and the U.S. firm Boeing are partners in Arrow. Washington has described its support for Israeli missile interceptors as a means of reassuring Israel, which in the past has launched preventative wars against perceived threats, that it has a more passive means of defending itself.

Israel has accused Iran of seeking to build nuclear weapons and has hinted it might strike the Islamic Republic in an effort to halt its atomic program.

Boeing thinks that potential clients for the system may include India, Singapore and South Korea.

"As we prove out that technology, and show that it's not only affordable but effective, we think there will be additional global market opportunities for that capability," Dennis Muilenburg, chief executive of Boeing's defense, space and security arm, told Reuters last year.

The United States and Israel have been developing Arrow jointly since 1988. Boeing's counterpart on the project is state-owned Israel Aerospace Industries.

The U.S. financial contribution to progressively improved versions of the Arrow system tops $1 billion, the Congressional Research Service said in a March 2012 report to lawmakers.

(Reporting by Dan Williams; Editing by Kevin Liffey)

Source: http://news.yahoo.com/israel-carries-arrow-missile-interceptor-test-official-064443952.html

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Carrot (for iPhone)


The uptick in public interest in "minimalist to-do apps" baffles me. It started with Clear (for iPhone) (99 cents, 2 stars), an app that offered a lovely interactive design, but failed completely at its one primary job of being an efficient to-do list. The iPhone app Carrot (99 cents) takes another stab at minimalist task mastering with an interactive twist by anthropomorphizing the app?and comes up similarly short. It's better than Clear, in my opinion, and more interesting, too, because it fully engages the user through human-computer dialogues. But it isn't an effective to-do list app.

Dangling the Carrot
Carrot, also known as "The To-Do List with a Personality," opens with a few quick tutorial pages that explain how the app works. You start by writing your to-do items on a fairly blank page (there's a header at the top). Drag down the screen to start a new entry. Hit "done" for the task to appear on your list. Swipe from left to right on any task to mark it as completed, and swipe right to left to reveal a menu. And that's it.

So far, Carrot probably sounds unreasonably simplistic, and it is. More functionality reveals itself as you use the app, but only after you earn it by ticking off your to-dos. For example, you should be able to reorder your tasks, right? You can, but only after you've completed a few of the things you've written down. It's one of the first features you'll unlock. If you think all task mastering apps should have a badge on its homescreen icon showing the number of outstanding items on your list, I'd agree?and so does Carrot, but only after you've unlocked three other features first.

Because of the way the app works, Carrot epitomizes the law of unintended consequences. To earn the additional functionality, you have to earn points, and the only way to earn points is by ticking off to-dos. You don't earn points for rearranging the items, revising them, or say, opening the app several times in a day. So, once you figure out this barrier, it's tempting to create meaningless to-dos just to tick them off just to earn the additional functionality... which is a big waste of time.

Missing Features
In using Carrot and unlocking the additional features, I'll admit that it's a cute gambit. The app responds as you use it, asking you to solve puzzles, or just praising you for getting your tasks done?see the slideshow for examples. It can be fun and interactively engaging, but it's not very utilitarian.

There are deadlines to set, no calendar view, no visual way to see priority among your tasks other than the stacked order. It doesn't have the ability to set a reminder on an upcoming task, and you can't take something from the "completed" section and move it back to the to-do list, a feature that I absolutely need because I make a lot of mistakes.

In testing, the app was also buggy. The gesture of swiping from right to left to reveal the menu occasionally just didn't work. Plus, that gesture only works from the main task screen. When I was in other screens, like one that explained a newly unlocked feature, I expected to be able to return to the menu, but couldn't. Instead, there's an X at the top to click to close the current screen. The inconsistency is annoying.

Carrot Alternatives
Carrot has some interesting ideas going for it in terms of design and interaction, but it isn't a to-do list app I can recommend for anyone who genuinely wants to create better to-do lists. PCMag's Editors' Choice for to-do apps on the iPhone is Awesome Note (+To-do/Calendar) ($3.99, 4 stars), and it's the one I recommend to most people. Another good alternative is Todoist (free, 3.5 stars), which syncs to a Web-based version as well for those who like to see and interact with their task list from a full-sized screen and not just on a smartphone. If you're looking for a to-do list that supports some level of collaboration, try Asana (free for up to 30 people, 4 stars)

More iPhone App Reviews:
??? Carrot (for iPhone)
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?? more

Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/fPenEL6tPpU/0,2817,2415935,00.asp

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Monday, February 25, 2013

Proposed Propane Tank Divides Searsport, Me.

[unable to retrieve full-text content]Supporters say the tank will bring much-needed jobs and boost the local economy; detractors warn it will be dangerous, blight the coastline, lower property values and drive away tourists.

Source: http://www.nytimes.com/2013/02/23/us/proposed-propane-tank-cleaves-searsport-me.html?partner=rss&emc=rss

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Historical society plans Washington, Frederick trip, and other news ...

Bus trip to Washington and Frederick planned

The Hanover Area Historical Society is sponsoring a bus trip to Washington, D.C., on Wednesday, March 20.

There will be stops at the Lincoln summer cottage, Basilica of the National Shrine in D.C. and the National Museum of Civil War Medicine in Frederick , Md.

The bus will leave at 7 a.m. from 1150 Carlisle St., Hanover, and return at approximately 6 p.m.

The cost for the trip is $85 and the deadline for reservations is March 4 by calling 717-624-2959.

Littlestown Lions fund field trips

The Littlestown Lions Club has come to the rescue of the Rolling Acres Third Grade field trips for a living history experience at the restored Mud College one-room schoolhouse.

The Lions, at a recent meeting, agreed to provide $300 to cover the cost of transportation for the seven third grade sections to spend a day at the old schoolhouse on Route 97 just north of Littlestown. The field trips have been an annual experience of the third graders, but were defunded in the school district's 2012-13 budget.

The field trips, which will see the students relive the lives of the students at Mud College in the late 1800s, will be held in May. Each current-day student will wear period dress and experience a typical day as it would have been in a one-room schoolhouse in 1896, including use of an outhouse, well pump for water and bag lunches as those earlier students would have had. Each student

will be assigned the identity of one of those former students for the day.

Classroom activities during the trip will encourage thinking about the many differences between the current days students' lives and those of the children who attended the school more than 100 years ago.

Courses planned at senior center

The Windy Hill Senior Center and OLLI (Osher Lifelong Learning Institute) at Penn State York will hold a kick-off event to announce their winter/spring course selections at 10 a.m. Tuesday, Feb. 26, at Windy Hill Senior Center, Spring Grove.

Participating in the program will be Mary Ligon, department chair of behavioral sciences at York College. She will discuss the health benefits of life-long learning for older adults. Several course instructors including Rick Santel, on the Hollywood Sampler, Laura Davila-Reyes on Peruvian Tappas, and Jeff Shue on Understanding the Local Infrastructure and Government Interaction will provide a brief glimpse of their courses.

Created in 2007, OLLI is a nonprofit, all volunteer driven organization, which provides educational and social programs to enrich the lives of mature adults living in York County. Windy Hill Senior Center is a drop-in activity center for older adults living in the Spring Grove community.

Refreshments will also be provided.

Contact the Windy Hill Senior Center at 717-225-0733 or OLLI at 717-0771-4015 for more information.

Donation opportunity to support agricultural education efforts

The York County Agriculture Business Council is seeking donations for the 27th Annual York County Agricultural Recognition Banquet Thursday, March 21, at the York Expo Center Old Main Hall.

By spotlighting York County businesses and products through a silent auction, the council's goal is to raise funds to support programs focused on educating the community about the importance of agriculture to York County's economy and way of life. Businesses or individuals could donate items from surplus inventory, promotional items or gift cards.

Donors will be recognized in the printed program and slide presentation.

Reservations for the banquet must be received by March 1. To donate an item or attend the banquet, contact Michele Grove at 717-246-3578 or ycabc@comcast.net.

Source: http://www.eveningsun.com/news/ci_22654178/historical-society-plans-washington-frederick-trip-and-other

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Sunday, February 24, 2013

Reprogramming cells to fight diabetes

Feb. 22, 2013 ? For years researchers have been searching for a way to treat diabetics by reactivating their insulin-producing beta cells, with limited success. The "reprogramming" of related alpha cells into beta cells may one day offer a novel and complementary approach for treating type 2 diabetes. Treating human and mouse cells with compounds that modify cell nuclear material called chromatin induced the expression of beta cell genes in alpha cells, according to a new study that appears online in the Journal of Clinical Investigation.

"This would be a win-win situation for diabetics -- they would have more insulin-producing beta cells and there would be fewer glucagon-producing alpha cells," says lead author Klaus H. Kaestner, Ph.D., professor of Genetics and member of the Institute of Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania. Type 2 diabetics not only lack insulin, but they also produce too much glucagon.

Both type 1 and type 2 diabetes are caused by insufficient numbers of insulin-producing beta cells. In theory, transplantation of healthy beta cells -- for type 1 diabetics in combination with immunosuppression to control autoimmunity -- should halt the disease, yet researchers have not yet been able to generate these cells in the lab at high efficiency, whether from embryonic stem cells or by reprogramming mature cell types.

Alpha cells are another type of endocrine cell in the pancreas. They are responsible for synthesizing and secreting the peptide hormone glucagon, which elevates glucose levels in the blood.

"We treated human islet cells with a chemical that inhibits a protein that puts methyl chemical groups on histones, which -- among many other effects -- leads to removal of some histone modifications that affect gene expression," says Kaestner. "We then found a high frequency of alpha cells that expressed beta-cell markers, and even produced some insulin, after drug treatment.

Histones are protein complexes around which DNA strands are wrapped in a cell's nucleus.

The team discovered that many genes in alpha cells are marked by both activating- and repressing-histone modifications. This included many genes important in beta-cell function. In one state, when a certain gene is turned off, the gene can be readily activated by removing a modification that represses the histone.

"To some extent human alpha cells appear to be in a 'plastic' epigenetic state," explains Kaestner. "We reasoned we might use that to reprogram alpha cells towards the beta-cell phenotype to produce these much-needed insulin-producing cells."

Co-authors are Nuria C. Bramswig, Logan Everett, Jonathan Schug, Chengyang Liu, Yanping Luo, and Ali Naji, all from Penn, and Markus Grompe, Craig Dorrell, and Philip R. Streeter from the Oregon Health & Science University. The Oregon group developed a panel of human endocrine cell type-specific antibodies for cell sorting.

The research was supported by the National Institute of Diabetes and Digestive and Kidney Diseases (U01 DK070430, U42 RR006042, U01DK089529, R01DK088383, U01DK089569) and by the Beckman Research Center/NIDDK/Integrated Islet Distribution Program (10028044).

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Story Source:

The above story is reprinted from materials provided by Perelman School of Medicine at the University of Pennsylvania.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Nuria C. Bramswig, Logan J. Everett, Jonathan Schug, Craig Dorrell, Chengyang Liu, Yanping Luo, Philip R. Streeter, Ali Naji, Markus Grompe, Klaus H. Kaestner. Epigenomic plasticity enables human pancreatic ? to ? cell reprogramming. Journal of Clinical Investigation, 2013; DOI: 10.1172/JCI66514

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/YsxoP3tN1kI/130223111356.htm

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We're live from MWC 2013 in Barcelona!

We're live from MWC 2013 in Barcelona!

We've arrived in Catalonia's capital city, where snow, apparently, has marked the start of this year's Mobile World Congress. That's right, the hills surrounding this typically warm Mediterranean metropolis have been blanketed in a thin layer of flurries, but we're nonetheless optimistic about this week's smartphone show in Barcelona. As MWC 2013's massive new venue begins to take shape, we're preparing to deliver the hottest hands-ons, directly from Fira Gran Via. Some manufacturers, such as HTC and LG, have already demoed their latest handsets, and other devices have made an early debut, but there's plenty of excitement still to come, as you'll discover in our show preview. We'll be sharing our liveblog lineup in a few hours -- for now, it's time to bookmark our event page, and check back often throughout the next week.

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Source: http://www.engadget.com/2013/02/23/live-from-mwc-2013/

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Saturday, February 23, 2013

PM says 'Japan's back,' vows stronger ties with US

President Barack Obama shakes hands with Japan's Prime Minister Shinzo Abe in the Oval Office of the White House in Washington, Friday, Feb. 22, 2013. (AP Photo/Charles Dharapak)

President Barack Obama shakes hands with Japan's Prime Minister Shinzo Abe in the Oval Office of the White House in Washington, Friday, Feb. 22, 2013. (AP Photo/Charles Dharapak)

President Barack Obama meets with Japan's Prime Minister Shinzo Abe in the Oval Office of the White House in Washington, Friday, Feb. 22, 2013. (AP Photo/Charles Dharapak)

Japanese Prime Minister Shinzo Abe, center, arrives at Andrews Air Force Base, Md., Thursday, Feb. 21, 2013. The Japanese prime minister is meeting President Barack Obama on Friday. (AP Photo/Manuel Balce Ceneta)

Japanese Prime Minister Shinzo Abe arrives at Andrews Air Force Base, Md., Thursday, Feb. 21, 2013. The Japanese prime minister will meet with President Barack Obama on Friday. (AP Photo/Manuel Balce Ceneta)

Japanese Prime Minister Shinzo Abe, arrives at Andrews Air Force Base, Md., Thursday, Feb. 21, 2013. The Japanese prime minister will meet with President Barack Obama on Friday. (AP Photo/Manuel Balce Ceneta)

(AP) ? Japan's new prime minister declared Friday he would make his country a stronger U.S. ally and joined President Barack Obama in warning North Korea that its recent nuclear provocations would not be tolerated.

After meeting Obama in the Oval Office, Prime Minister Shinzo Abe also sent a clear message to China: that while Japan does not want confrontation with Beijing, it won't tolerate challenges to its sovereignty over islands disputed by the two Asian powers.

Those regional tensions served as the backdrop for Friday's meetings, which came just two months after Abe began his second stint as Japan's prime minister following a convincing election victory.

Obama said he and Abe were united in their "determination to take strong actions" in response to North Korea's nuclear test this month, which followed a successful long-range rocket launch last month. That has propelled the isolated, authoritarian state closer to having a weapon of mass destruction that could threaten the U.S.

Abe said he and Obama have agreed to push for tougher sanctions by the U.N. Security Council and spelled out why Pyongyang's actions are cause for worry.

"They (North Korea) have increased the range of their missile immensely and have attained the ability to reach even the mainland United States," Abe said at a Washington think tank after his White House visit. He said Pyongyang was also claiming it has made a smaller nuclear bomb that could be delivered by missile.

Speaking through a translator, the Japanese leader said this was why the United States was pressuring China to exert more influence over its North Korean ally. Abe said it was important for the entire international community to do the same.

Most experts believe North Korea is still some years away from being able to hit America, although its shorter-range missiles could already threaten its neighbors.

Abe, a nationalist and advocate of Japanese relations with the United States, is the latest in a revolving door of Japanese prime ministers ? the fifth since Obama took office. That's made it difficult to establish a personal rapport between Japanese and U.S. leaders, notwithstanding the enduring nature of the bilateral relationship. Japan hosts about 50,000 American forces and is a cornerstone of Washington's Asia policy.

His first stint as prime minister was cut short in 2007 by ill health, but Abe's now riding high in the polls. He outlined Friday his policy to revive his nation after years of malaise by building a strong economy and strong national defense.

"Japan is not, and will never be, a tier-two country," Abe said. "That is the core message I am here to make. And I reiterate this by saying, I am back, and so shall Japan be."

He promised to enhance Japan's role in international affairs, build its cooperation with other democracies and promote open use of the seas and rules-based trade.

Japan's relationship with Washington has assumed more importance for Tokyo in recent months as it has locked horns with China over the control of unoccupied islands in the resource-rich seas between them.

The dispute flared after Tokyo nationalized some of the islands in September. China also claims the tiny islands, which it calls Diaoyu. It has stepped up patrols into what Japan considers its territorial waters, heightening concern that a conflict could be sparked. The tensions highlight the rivalry between China, the world's second-largest economy, and Japan, which is the third.

Obama did not address the dispute in his brief remarks, but separately, Secretary of State John Kerry complimented Japan on the restraint it has shown and its efforts to prevent a "significant confrontation."

Abe said that Japan had no intention of escalating the dispute and that his door was always open to Chinese leaders.

But he had some words of defiance, too, over Japan's sovereignty of the islands.

"We simply cannot tolerate any challenge now and in the future," Abe said. "No nation should make any miscalculation about firmness of our resolve. No one should ever doubt the robustness of the Japan-U.S. alliance."

The U.S. has treaty obligations to help Japan in the event of a conflict, obligations Abe said were a stabilizing factor in ensuring peace and stability in the region.

In comments that will be welcomed by Washington, Abe held out an olive branch to South Korea, a key U.S. ally that shares Japan's concern over North Korea's provocations.

He said the Japan-South Korea relationship was "extremely important" and he wanted to resolve the differences between them. The two Asian democracies have bickered over another island dispute, and Seoul believes Tokyo lacks contrition for its colonial past and use of Korean sex slaves during World War II.

Friday's meeting was an opportunity for the U.S. to gauge Tokyo's intent to join negotiations on the Trans-Pacific Partnership, or TPP, a regionwide free-trade pact pushed by Washington.

Abe held back from such a commitment that could prove politically risky before key elections in July for the upper house of the legislature, known as the Diet. Joining TPP is opposed by most of his party and Japan's small but politically powerful farming lobby.

However, a joint statement said the two leaders had agreed to continue their talks about Japan's "possible interest" in joining TPP. It appeared to offer some new wiggle room for Abe. It acknowledged sensitivities for Japan on certain agricultural products and for some manufactured products for the U.S.

The statement said that while all goods would be subject to negotiation, a prior commitment to eliminate all tariffs was not required.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-02-22-US-US-Japan/id-061886cd94a846faa07e97b60edc8f87

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Rich David will not run for Binghamton Mayor

By Kelly McCarthy

Rich David will not run for Binghamton Mayor

February 23, 2013 Updated Feb 23, 2013 at 10:11 AM EST

Binghamton, NY (WBNG Binghamton) Richard David announced he will not seek the Republican nomination for Binghamton Mayor in November.

David attributes problems paying property taxes for his commercial buildings in Binghamton as the reason he will not seek office.

In a statement sent on Friday David said, ?I worked hard to pay off the balance, with interest, as soon as possible, and am current on all my tax obligations. However, I believe those seeking higher office should be held to a higher standard.?

David is a real estate and business owner and works as public information officer at Broome Community College.

He ran against Mayor Matthew Ryan in the 2009 election.

Source: http://www.wbng.com/news/local/David-will-not-run-192705211.html

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Watch: Film Spotlights Beauty Parlor Catering to Cancer Patients

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-- -- Well not -- if they remain patient and crying for me to say goodbye to my hair it's. Definitely. It's making the point that now I have to traced -- yes I am a cancer patient. So for me. It's devastating. It's like your -- your identity and that's been taking. And you are -- to -- and then your eyelashes fall out. We feel like you being increased because of cancer I don't feel like a woman and I feel I can tell -- I got LA clippers and Ken wiwa and an -- Shaved her head and -- like -- -- twins at that point. Okay. You.

This transcript has been automatically generated and may not be 100% accurate.

Source: http://abcnews.go.com/Health/video/film-spotlights-beauty-parlor-catering-cancer-patients-18561963

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Play the Slate News Quiz?Special Oscars Edition!

It's Oscar weekend, which is pretty much Super Bowl weekend for people who don't go outside much, or played an instrument in high school, or are women. (Or some perfect-storm combination of the three!) How closely have you been following the run-up to the 85th annual Academy Awards? You'll be able to find out with this special Oscars edition of the Slate News Quiz. Make sure to answer each one as quickly as you can, before the orchestra starts playing you off.

Question 1 of 12

What is the age difference between the youngest and oldest nominees in the Best Actress category this year?

Quvenzhan? Wallis, of Beasts of the Southern Wild, is 9, while Emmanuelle Riva of Amour is 85. They are, respectively, the youngest and oldest nominees ever in the category.

Question 2 of 12

If Argo wins Best Picture, as many have predicted, it will be the first Best Picture winner since Driving Miss Daisy ...

Ben Affleck was shut out of the category, in one of the most surprising upsets of the nominations.

Question 3 of 12

Les Mis?rables is the second movie of that title to be nominated for Best Picture. (The first was in 1935.) Which of these movie titles has also been the name of two different Best Picture nominees?

There have been four other twice-nominated titles: Cleopatra, Heaven Can Wait, Moulin Rouge, and Romeo and Juliet.

Question 4 of 12

The title character of which nominated film faces opponents with names like Taffyta Muttonfudge, Jubileena Bing Bing, and Rancis Fluggerbutter?

In Wreck-It Ralph, Taffyta and friends are among the not-very-nice racers in the fictional go-kart game Sugar Rush.

Question 5 of 12

What was "grossly inaccurate and misleading," according to a controversial Dec. 19 letter sent by three U.S. senators to Sony Pictures?

The film was seen as a Best Picture front-runner in December, but the torture blowback seems to have dimmed its chances.

Question 6 of 12

Until this year, longtime Academy Awards musical conductor Bill Conti was also the last person to be Oscar-nominated?31 years ago?for what?

Before Skyfall's five nominations, Conti received the last nod for a 007 film, for his 1981 title tune for For Your Eyes Only.

Question 7 of 12

Oscar host Seth MacFarlane is also a nominee this year?in which category?

MacFarlane wrote the lyrics to "Everybody Needs a Best Friend," from his directorial debut, Ted.

Question 8 of 12

How many Oscar statuettes' worth of weight did Hugh Jackman and Anne Hathaway lose, in total, for their parts in Les Mis?rables?

Oscar weighs 81/2 pounds. Hathaway says she lost 25 pounds for Les Mis while Jackman lost 15.

Question 9 of 12

Which film is nominated in all four acting categories, the first time this has happened since Reds in 1981?

The four nominees are Bradley Cooper, Jennifer Lawrence, Robert De Niro, and Jacki Weaver.

Question 10 of 12

Which of these is true about Daniel Day-Lewis' immersive preparation for his role as Abraham Lincoln?

Question 11 of 12

Amour is nominated for both Best Picture and Best Foreign Language film. Which film last accomplished this?

Question 12 of 12

Which of this year's nominees actually submitted a script back in 1979 to Studio Six, the phony CIA-backed production company depicted in Argo?

Former CIA agent Tony Mendez says that Studio Six received 26 scripts before shutting down, including one from Spielberg.

You got 8 out of 12 answers correct in 20 minutes 30 seconds.

Source: http://feeds.slate.com/click.phdo?i=7c169731cf4a1e7e857b035db7ff75bc

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Job candidates sometimes make the decision easy ? Business ...

Here are some real-life examples of what job candidates have told hiring managers, according to a recent CareerBuilder.com report:

  • Candidate said he had to quit a banking position because he was always tempted to steal.
  • Candidate denied that he had a cellphone with him even though it could be heard ringing in his briefcase.
  • Candidate said he didn?t like getting up early and didn?t like to read.
  • Candidate asked to be paid ?under the table.?
  • Candidate commented that he would do whatever it takes to get the job done, legal or not.
  • Candidate said he didn?t want the job if he had to work a lot.
  • Candidate wouldn?t answer a question because he thought they would steal his idea and not hire him.

Like what you've read? ...Republish it and share great business tips!

Attention: Readers, Publishers, Editors, Bloggers, Media, Webmasters and more...

We believe great content should be read and passed around. After all, knowledge IS power. And good business can become great with the right information at their fingertips. If you'd like to share any of the insightful articles on BusinessManagementDaily.com, you may republish or syndicate it without charge.

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Source: http://www.businessmanagementdaily.com/34557/job-candidates-sometimes-make-the-decision-easy

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Friday, February 22, 2013

Twists and Turns in South Africa

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Source: http://www.nytimes.com/video/2013/02/21/world/africa/100000002077905/twists-and-turns-in-south-africa.html

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Floating Books and Multiple Screens: The Traditional Yet High-Tech Workspace

Floating Books and Multiple Screens: The Traditional Yet High-Tech WorkspaceOld meets new in today's featured workspace, which is outfit with classic white shelves and country-style curtains, but also blends in several screens and other gadgetry.

Flickr user abe5x's workspace has a traditional feel, thanks to the many books, wooden picture frames, and other decorative elements. The long L-shaped wooden desk is spacious and houses five monitors. Somehow even the JBL Creature speakers blend into the decor. There's a large whiteboard off to the right side of the desk, out of view in this photo but shown in abe5x's photostream linked below.

If you have a workspace of your own to show off, post them to #workspaceshowcase. Make sure any photos you include are at least 640x360. Keeping them to 16:9 helps, too! Include a little text about the stuff you used, how you came up with the design, and any other relevant details. If your clever organization and good design sense catches our eye, you might be the next featured workspace.

Abexx Home Office Feb. 2013 | Flickr

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/WKrs4ht0JRc/floating-books-and-multiple-screens-the-traditional-yet-high+tech-workspace

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Thursday, February 21, 2013

Wall Street ends lower on growth worries

NEW YORK (Reuters) - U.S. stocks fell for a second straight day on Thursday and the S&P 500 posted its worst two-day loss since November after reports cast doubt over the health of the U.S. and euro-zone economies.

But a late-day rally helped stocks erase some of their losses with most of the pullback concentrated in the technology- heavy Nasdaq. The move suggested investors were still willing to buy on dips even after the sharp losses in the last session.

In Europe, business activity indexes dealt a blow to hopes that the euro zone might emerge from recession soon, showing the downturn across the region's businesses unexpectedly grew worse this month.

"The PMI numbers out of Europe were really a blow to the market," said Jack De Gan, chief investment officer at Harbor Advisory in Portsmouth, New Hampshire. "The market was expecting signs that recovery is still there, but the numbers just highlighted that the euro-zone problem is still persistent."

U.S. initial claims for unemployment benefits rose more than expected last week while the Federal Reserve Bank of Philadelphia said its index of business conditions in the U.S. mid-Atlantic region fell in February to the lowest in eight months.

Gains in Wal-Mart Stores Inc shares helped cushion the Dow. The shares gained 1.5 percent to $70.26 after the world's largest retailer reported earnings that beat expectations, though early February sales were sluggish.

The Dow Jones industrial average <.dji> fell 46.92 points, or 0.34 percent, to 13,880.62 at the close. The Standard & Poor's 500 Index <.spx> lost 9.53 points, or 0.63 percent, to 1,502.42. The Nasdaq Composite Index <.ixic> dropped 32.92 points, or 1.04 percent, to close at 3,131.49.

The two-day decline marked the U.S. stock market's first sustained pullback this year. The Standard & Poor's 500 has fallen 1.8 percent over the period and just managed to hold the 1,500 level on Thursday. Still, the index is up 5.3 percent so far this year.

The abrupt reversal in markets, which started on Wednesday after minutes from the Federal Reserve's January meeting suggested stimulus measures may end earlier than thought, looks set to halt a seven-week winning streak for stocks that had lifted the Dow and the S&P 500 close to all-time highs.

Wall Street will soon face another test with the upcoming debate in Washington over the automatic across-the-board spending cuts put in place as part of a larger congressional budget fight. Those cuts, set to kick in on March 1 unless lawmakers agree on an alternative, could depress the economy.

Semiconductor stocks ranked among the weakest of the day, pressuring the Nasdaq as the Philadelphia Semiconductor Index <.sox> fell 1.8 percent. Intel Corp fell 2.3 percent to $20.25 while Advanced Micro Devices lost 3.7 percent to $2.60 as the S&P 500's biggest percentage decliner.

The Dow also got a helping hand from personal computer maker Hewlett-Packard Co , which rose 2.3 percent to end the regular session at $17.10. The company was scheduled due to report first-quarter results after the closing bell.

Shares of Boeing Co rose 1.6 percent to $76.01 as a senior executive was set to meet with the head of the U.S. Federal Aviation Administration on Friday and present a series of measures to prevent battery failures that grounded its 787 Dreamliner fleet, according to a source familiar with the plans.

In other company news, shares of supermarket operator Safeway Inc jumped 14.1 percent to $22.97 after the company reported earnings that beat expectations.

Shares of VeriFone Systems Inc tumbled nearly 43 percent to $18.24 after the credit-card swipe machine maker forecast first- and second-quarter profits well below expectations.

Of the 427 companies in the S&P 500 that have reported results so far, 69.3 percent have exceeded analysts' expectations, compared with a 62 percent average since 1994 and 65 percent over the past four quarters, according to Thomson Reuters data through Thursday morning.

Fourth-quarter earnings for S&P 500 companies are estimated to have risen 5.9 percent, according to the data, above a 1.9 percent forecast at the start of the earnings season.

Berry Petroleum Co jumped 19.3 percent to $46.02 after oil and gas producer Linn Energy LLC said it would buy the company in an all-stock deal valued at $4.3 billion, including debt. Linn Energy shares advanced 2.8 percent to $37.68.

About two stocks fell for everyone that rose on the New York Stock Exchange and Nasdaq. About 7.64 billion shares changed hands on the New York Stock Exchange, the Nasdaq and NYSE MKT, well above the 20-day moving average of around 6.6 billion shares.

(Editing by Jan Paschal)

Source: http://news.yahoo.com/stock-futures-lower-flurry-data-tap-123208226--sector.html

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